Nekhorvich, an old friend of Hunt, had forewarned the IMF of his arrival, planning to deliver a new virus called Chimera and its cure, Bellerophon, both of which he was forced to develop by Biocyte, into the IMF's hands. With the crash of the plane, IMF is worried that the virus is out in the open, believing that former IMF agent Sean Ambrose (Dougray Scott) is behind the incident. IMF assigns Hunt and his team to recover it, but must include Nyah Nordoff-Hall (Thandie Newton), a professional thief, presently operating in Seville, Spain, as she will be able to get close to Ambrose.
After recruiting Nyah, Hunt meets his team, computer expert Luther Stickell (Ving Rhames) and pilot Billy Baird (John Polson) in Sydney, Australia, where Biocyte laboratories are located along with Ambrose's headquarters. As Hunt and the others stake out Biocyte, Nyah gets close to Ambrose and begins to find any information related to the Chimera virus. At a horse racing event, Ambrose quietly meets with Biocyte's CEO, John C. McCloy (Brendan Gleeson), and shows him a video of the Chimera virus affecting one of Nekhorvich's colleagues taken from Biocyte, using the footage to force McCloy to cooperate with them. Nyah is able to steal the video footage long enough to transfer it to Hunt and his team, who learn that the Chimera virus has a 20 hours dormant period before it causes mass destruction of the victim's blood cells and kills them.
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